Description
What is Tramadol?
Tramadol is a centrally-acting opioid analgesic that is used to treat the pain of various types and intensities.
Tramadol indications for use
Tramadol is commonly used as an analgesic and is used to treat persistent moderate to severe pain. The analgesic potency is comparable to that of morphine.
It is also suitable for the treatment of neuropathic pain, for pain relief for fibromyalgia, and for pain relief for toothaches and headaches.
In people with osteoarthritis, tramadol reduces the intra-articular concentration of Substance P and interleukin-6. This significantly reduces the pain caused by inflammation in the joint.
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Tramadol anti-inflammatory
Tramadol is not an anti-inflammatory drug, it only relieves the pain of varying severity.
Mechanism of action Tramadol
Tramadol is an opioid analgesic of central action. The active ingredient binds to μ-, δ-, and κ-opioid receptors. In addition, the active ingredient inhibits serotonin and norepinephrine reuptake.
Tramadol has analgesic and anti-cough effects, but does not have an inhibitory effect on respiration in a wide range of doses and does not affect the motility of the gastrointestinal tract.
Pharmacokinetics of Tramadol
More than 90 percent of Tramadol is absorbed after oral administration and has an absolute bioavailability of about 70 percent, regardless of food intake. The drug undergoes little first-pass metabolism, and about 20 percent binds to serum proteins.
Tramadol penetrates the blood-brain barrier and the placenta and is excreted with breast milk. The elimination half-life is about 6 hours regardless of administration.
Tramadol is mainly excreted via the kidneys, therefore a slight prolongation of the elimination half-life in hepatic and renal impairment should be expected.
Tramadol vs Oxycodone
Tramadol and Oxycodone are prescription painkillers you may be prescribed for moderate to severe pain when other treatments have not worked. Oxycodone and Tramadol interact with the brain’s opioid receptors, reducing the transmission of pain signals. They can be used to treat different types of pain, including musculoskeletal pain and postoperative pain.
When Tramadol first appeared, it was not classified as a controlled substance. In 2014, the Drug Enforcement Administration (DEA) reclassified Tramadol as a Schedule IV controlled substance. Tramadol can be abused, and its use should be carefully monitored.
Oxycodone is a Schedule II controlled substance. It has a very high potential for addiction, abuse, and withdrawal.
Both medications must be taken every 4-6 hours, are not to have overdosed, and the duration of therapy should not be longer than 7 days.
Both drugs effectively eliminate pain, but each requires special care in their use.
Tramadol schedule
The dosage of tramadol depends on the severity of the pain and the individual sensitivity of the patient.
For adults and adolescents over 12 years of age, the drug can be taken 50-100 mg as recommended by the physician to relieve pain every 4-6 hours, but not more than 400 mg/day. (except for long-acting drugs, they should be taken less frequently!).
Tramadol dosage for arthritis
Depending on the intensity of the pain, it is necessary to take the drug according to the doctor’s instructions, without exceeding the maximum allowable amount.
Tramadol headache
Tramadol from Mexico reduces the severity of pain and photophobia associated with migraine headaches. It should be taken as directed or indicated by your doctor until the pain has gone away, but no more than 3 times a day.
Can you crush Tramadol pills?
The tablet or capsule containing Tramadol must be swallowed whole. It must not be broken, crumbled, or chewed. Also, the route of administration should not be changed; it should only be taken orally.
Tramadol side effects
The most commonly reported side effects (≥10 percent of patients) are nausea and dizziness.
The following side effects may also occur frequently (≥1/100 to <1/10):
- Headache
- Drowsiness
- Vomiting
- Constipation
- Dry mouth
- Sweating
- Fatigue
Tramadol side effects in elderly
The possibility of side effects increases in elderly patients. The most common are dizziness, fainting, nausea, and vomiting.
Does Tramadol make you sleepy?
One of the most common side effects of the drug is drowsiness.
Does Tramadol cause constipation?
Tramadol can cause constipation. If any side effects occur, it is necessary to consult a physician urgently; therapy may be corrected.
Contraindications
Tramadol should not be taken if there is: known hypersensitivity to tramadol, acute intoxication with alcohol, sleeping pills, analgesics, opioids and psychotropic agents, epilepsy, or substitution therapy.
Pregnancy and breastfeeding
If tramadol is to be used during pregnancy, it should be limited to single doses. Prolonged use should be avoided because tramadol penetrates the placenta and withdrawal symptoms may occur after birth in newborns.
Tramadol should not be used during breastfeeding. However, there is usually no need to stop breastfeeding after a single dose of tramadol.
Driving ability
Because tramadol use may cause drowsiness and dizziness, the ability to drive and operate machinery is impaired under these conditions.
Tramadol interactions
The following interactions are possible when taking Tramadol:
- Tramadol should not be used concomitantly with MAO inhibitors.
- Concomitant use of central depressants
- Concomitant use of carbamazepine (enzyme inducer) results in decreased serum concentrations of tramadol
- In mixed agonist/antagonist combinations (e.g., buprenorphine, nalbuphine, pentazocine), the analgesic effect of pure agonist may be impaired.
- Coumarin derivatives (e.g., warfarin) – increased INR and ecchymosis are possible.
Not all possible interactions are listed; our experienced pharmacists can advise you on this when ordering Tramadol online.
Tramadol online
You cannot buy Tramadol without a prescription because this drug is sold only with a prescription.
But you can buy Tramadol online at an attractive price in our online pharmacy, with a free consultation from our specialists. Tramadol 50 mg price depends on the manufacturer and the quantity of the drug.
Before taking tramadol
- You should not take tramadol if you have ever been addicted to drugs or alcohol, if you are currently intoxicated (drunk), or if you have recently used any of the following drugs: alcohol; narcotic pain medicine; sedatives or tranquilizers (such as Valium); medicine for depression or anxiety; medicine for mental illness (such as bipolar disorder, schizophrenia); or street drugs.
- Seizures have occurred in some people taking tramadol.
- Your risk of a seizure may be higher if you have any of these conditions: a history of drug or alcohol addiction; a history of epilepsy or other seizure disorder; a history of head injury; a metabolic disorder; or if you are also taking an antidepressant, muscle relaxer, or medicine for nausea and vomiting.
- Talk with your doctor about your individual risk of having a seizure while taking tramadol.
- Before taking tramadol, tell your doctor if you are allergic to any drugs, or if you have: kidney disease; liver disease; a stomach disorder; or a history of depression, mental illness, or suicide attempt.
- If you have any of these conditions, you may need a dose adjustment or special tests to safely take tramadol.
- Please consult your personal physician before taking any type of medication.
Information about buying tramadol
- You can buy tramadol 50mg at an affordable price.
- “Tramadol” is the international unpatented name of the drug (TM Ultram, Ultram EP). The active substance is tramadol hydrochloride in an amount of 50 mg.
- The drug belongs to the group of potent opioid analgesics and is used for moderate to high pain. It affects the spinal cord and stops the conduction of pain impulses. It has a depressant effect on norepinephrine and releases serotonin.
- Tramadol 50mg is prescribed in the period after surgery, with intense pain after trauma, to patients who suffer from oncological diseases. It is also used in some cases in the diagnosis and treatment procedures to eliminate pain.
- Important! The drug should not be taken after drinking alcohol, drugs, and psychotropic drugs, sleeping pills. Also, tramadol 50mg should not be consumed while taking MAO inhibitors and 2 weeks after the end of their intake.
- The time until the active action of the drug can take longer if you have had a head injury or a metabolic disorder in the past, and if you are taking drugs for depression, remedies that eliminate nausea and vomiting, or muscle relaxants.
- You can buy tramadol after prescribing by a doctor, as with different intensity of pain different dosages are prescribed. This drug should not be taken for too long, as well as abruptly cancel it because of the risk of side effects.
- In the online pharmacy Relief Meds Store, you can purchase tramadol at a low price and order delivery to [location]. Select a delivery service, and your order will arrive within 15-30 business days.
- Tramadol should not be taken with drugs that depress the action of the central nervous system. Also, during the reception, you should not consume alcohol and drugs. Refrain from driving the vehicle, the drug may cause drowsiness and diffuse attention. When feeding with breast milk, a single dose of tramadol is allowed. A longer reception is not recommended.
Mechanism of action
Tramadol Citra 50, like other forms of tramadol, operates through a dual mechanism of action to alleviate pain.
-
Opioid Receptor Agonism: Tramadol is an agonist of the mu-opioid receptors, which are involved in the perception of pain and the body’s pain response. By binding to these receptors, tramadol mimics the action of endogenous opioids (like endorphins), reducing the perception of pain in the body.
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Reuptake Inhibition: Tramadol also acts as a reuptake inhibitor for the neurotransmitters serotonin and norepinephrine. This means it prevents these neurotransmitters from being absorbed back into the nerve cells in the brain and spinal cord after they have been released. This inhibition results in an increase of these neurotransmitters in the synaptic cleft (space between neurons), which helps to modulate and decrease the pain signals, thus enhancing pain relief.
These two actions together give tramadol its unique pain-relieving properties. It’s important to note, however, that the body can develop a tolerance to tramadol over time, and the drug should only be taken under the supervision of a healthcare provider due to its potential for dependence and addiction.
Dosage and Administration
Tramadol 50mg tablet is generally taken orally with or without food. However, if you have nausea, taking the medication with food may help reduce this symptom.
As for the dosage, it greatly depends on the patient’s medical condition and response to treatment. The usual recommended dose for adults is 50-100mg every four to six hours as needed for pain. The maximum recommended daily dose is 400mg. For some patients, starting at a lower dose (25mg/day) and gradually increasing the dosage may help reduce side effects.
Remember to take Tramadol pills 50mg exactly as prescribed by your healthcare provider. It’s important to follow the instructions carefully to avoid risks such as addiction or overdose. It’s also crucial not to suddenly stop taking this medication without discussing it with your doctor, as this can lead to withdrawal symptoms.
In the case of elderly patients, or patients with liver or kidney issues, the dosage might be adjusted by your healthcare provider due to slower metabolism and excretion of the drug.
For the best effects, this medication should be taken regularly. If it’s taken for a prolonged period, it may not work as effectively and may require a different medication strategy.
Potential Side Effects
As with any medication, Tramadol 50 can cause side effects. The most common ones include nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, or sweating. These side effects may decrease as your body gets used to the medication. If these side effects persist or worsen, seek medical attention immediately.
Serious side effects are less common but may include mental/mood changes (such as agitation, hallucinations), severe stomach/abdominal pain, difficulty urinating, signs of your adrenal glands not working well (such as loss of appetite, unusual tiredness, weight loss). In case of any serious side effects, you should contact your doctor promptly.
Precautions and Warnings
Certain conditions may contraindicate the use 50mg of Tramadol, such as severe asthma or breathing problems, a blockage in the stomach or intestines, if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications, or if you have used an MAO Inhibitor in the past 14 days.
Tramadol Citra may be habit-forming, and misuse can lead to addiction, overdose, or death, especially in a person using the drug without a prescription. Therefore, it’s critical to take this medication exactly as prescribed by your healthcare provider.
Interactions
Certain medications may interact with Tramadol Citra 50, including other opioid pain medications, mental health drugs (like antidepressants or antipsychotics), certain antibiotics, and heart medications. Always inform your healthcare provider about all the medications you are currently taking to avoid harmful interactions.
Citra Tramadol 50mg and Special Populations
The use of Tramadol pills 50 mg should be closely monitored in children, the elderly, pregnant women, and breastfeeding mothers. For elderly patients, the dosage may need to be adjusted as their liver and kidney function may not be as efficient, causing the drug to be processed more slowly.
Pregnant women should avoid using Tramadol 50 mg pill as it could potentially harm the unborn baby. In addition, traces of Tramadol can pass into breast milk and may cause side effects in a nursing infant. Therefore, breastfeeding mothers should discuss the potential risks and benefits with their healthcare provider before taking this medication.
In patients with liver or kidney disease, a lower dose or extended dosing interval may be required as these conditions may affect how the active substance is metabolized and eliminated from the body.
What to Do in Case of Overdose
Overdosing Tramadol 50 mg can be life-threatening. Symptoms of overdose can include slow breathing, slow heartbeat, severe drowsiness, fainting, and coma.
Proper Storage and Disposal
Citra Tramadol should be stored at room temperature, away from light and moisture. Do not store it in the bathroom. Unused or expired medications should be disposed of properly to prevent accidental consumption.
Frequently Asked Questions
Q: Can I drink alcohol while taking Citra Tramadol 50mg?
A: No, combining alcohol with Tramadol can lead to dangerous side effects or death.
Q: Can I drive or operate heavy machinery while taking this medication?
A: Tramadol can impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you.
Q: Can I stop taking Tramadol abruptly?
A: No, stopping Tramadol suddenly can lead to withdrawal symptoms. Always consult with your healthcare provider for a safe discontinuation plan.
Q: How strong is 50 mg of Tramadol?
A: Tramadol is a potent prescription painkiller. A 50mg dose of Tramadol is a relatively moderate dose, but its strength and effectiveness can vary significantly depending on the individual taking it. Factors like body weight, overall health, the type and intensity of pain being treated, and individual sensitivity to the medication can all influence how “strong” a 50mg dose of Tramadol may feel.
It’s also worth noting that Tramadol has a dual mechanism of action. It works both as an opioid pain reliever and as a medication that affects serotonin and norepinephrine, neurotransmitters in your brain. This unique mechanism contributes to its pain-relieving capabilities.
That said, it’s crucial to take Tramadol only as directed by a healthcare professional. Even though 50mg is not a high dose, misuse of Tramadol can still lead to serious side effects, including dependency and overdose. If you feel that your current dose is not effectively managing your pain, you should consult with your doctor rather than increasing the dose on your own.
Q: How to take tramadol 50 mg for nerve pain?
A: Tramadol 50mg is typically used for moderate to moderately severe pain, including nerve pain. The way you take it can depend on the specific product you are prescribed, your individual medical condition, and your body’s response to treatment.
Here are general instructions for taking Tramadol:
When and How Often to Take It: Tramadol is usually taken every 4 to 6 hours as needed for pain relief. You should not take more than the maximum recommended dose (usually 400 mg per day for adults) in any 24-hour period.
Taking it With or Without Food: Tramadol can be taken with or without food. However, if the medication makes you feel nauseous, taking it with food may help reduce this symptom.
Swallowing the Tablet: Swallow the tablet whole with a drink of water. Do not crush, break, or chew it. This is particularly important for extended-release forms of the medication, which are designed to release the drug slowly over time.
Follow Your Doctor’s Instructions: Always follow your doctor’s instructions about when and how to take your medication. Your doctor will determine the most appropriate dosage for your specific needs, based on factors like your pain level, other medications you’re taking, and your overall health status.
It’s important to note that while Tramadol can help manage nerve pain, it does not cure the underlying cause of the pain. Therefore, it should be used as part of a comprehensive treatment plan that may include other medications, physical therapy, or other treatments as advised by your healthcare provider.
As with any medication, Tramadol can have side effects and has the potential for dependence and abuse.
It’s essential not to suddenly discontinue Tramadol without consulting with your healthcare provider, as this could lead to withdrawal symptoms. Your doctor can provide guidance on how to safely stop using this medication if it’s necessary.
Citra Tramadol 50mg is a powerful medication for managing moderate to severe pain. While it can significantly improve the quality of life for those struggling with pain, it must be used responsibly due to its potential for addiction and dependence. Always follow your healthcare provider’s instructions regarding dosage and duration of treatment, and report any side effects promptly.
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