Anti-inflammatory and antifibrotic drug KitosCell-LP, which is prescribed by doctors for the treatment of pulmonary and liver fibrosis.
Pharmaco-therapeutic group: Immunosuppressive agent.
Composition of KitosCell – LP:
Brand Name: Kitoscell (Esbriet).
Generic Name: Pirfenidon.
Kitos Cell – LP Mexican cheap analogue of the anti-fibrotic drug Esbriet from the Swiss manufacturer.
Pirfenidone is a drug with pleiotropic effects with antifibrotic, anti-inflammatory and antioxidant properties.
Always take this medication exactly as directed in the package insert, or as directed by your doctor or pharmacist. If you are unsure, check with your doctor or pharmacist.
- Idiopathic pulmonary fibrosis;
- Liver fibrosis.
Also, among the indications for the appointment of KitosCell-LP are inflammatory diseases associated with liver fibrosis or pulmonary fibrosis.
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Contraindications Kitoscell LP 600 mg
Before using the tablets, be sure to read all the contraindications, if you have any additional questions, then contact your pharmacist.
Medicines based on Pirfenidone is contraindicated for children under 18 years.
The medicine Kitocell is not recommended:
- Intolerance and allergy to Pirfenidone;
- Severe kidney failure;
- Liver failure.
FDA Recommendations – Category C, Fetal Effects.
Pirfenidone Kitoscell Application Area
Both liver and lung fibrosis can become the main reason for lesions on the human internal parts. The patient can decrease the negative impact of the disease with the help of Kitoscell LP that cuts down the harmful processes and reduces the development of lesion-affected cells. The form of a disease matters when it comes to the dosage of this medication and the treatment plan scheduled by the doctor.
Dosage and method of administration of KitosCell LP
The average dosage for adult patients is 1200-2400 mg of the generic per day. As one pill contains 600 mg of the active agent, it is required to take 2-4 tablets daily. For better absorption of the Kitoscell medication, the doctor recommends using pills right after meals. The tablet should be taken with a sufficient amount of water. It is not recommended to dissolve the pill in the mouth.
The most optimal break between the intakes is 12 hours. If the patient should use more than 2 pills daily, the intervals can be 6-8 hours between the Kitoscell administration cases. Children with lung or liver fibrosis should use 600-1200 mg of Pirfenidone every day.
It is worth noting that Kitoscell doses should be increased gradually. This way, most side effects are prevented, and the organism starts accumulating the active agent with no stress for the digestive system and other internal processes. The average dosage plan for treatment with the help of the Kitoscell generic is:
Day 1-4: 900 mg a day (three doses x 300 mg). The patient should take half of the pill every 8 hours.
Day 5-14: 1200 mg a day (four doses x 300 mg). The patient should use half of the pill every 6 hours.
Day 15-21: 1200 mg a day (two doses x 600 mg). One pill should be taken every 12 hours daily.
Day 21-30: 1200-2400 mg a day (two-four doses x 600 mg). One pill should be taken every 12 hours daily if the recommended dosage is 1200 per day. If the sufficient dose is 2400 mg, the patient should use 2 pills of Kitoscell at once with an interval of 12 hours.
It is worth noting that the average treatment courses last about 1 calendar month. Then, the healthcare specialist examines the patient to understand the progress. The dosage plan can be changed before the next stage of the therapy takes place. It is recommended to have a 2-week break before the second and third courses.
You can buy KitosCell – LP online in the USA from an online Mexican pharmacy without a prescription.
Kitoscell for the Anti-Scarring Therapy
In some cases, one month of Kitoscell intake is enough to do away with the disease. The minimum dosage of this medication is prescribed to patients with scars and stretch marks. If the main purpose is to remove sword cuts and other imperfections on the skin, it will be enough to take ½ pill 2 times a day during 2-3 weeks.
If the patient has internal scars and cicatrix marks, it is better to consult the doctor first. First, the ultrasound investigation takes place. If there is myocardial scarring or uterine scars, the treatment course can last about 1 calendar month but with the minimum daily doses of Pirfenidone Kitoscell LP (600-1200 mg / 1-2 tablets per day).
KitosCell-LP side effects and precautions
Medical advice: Talk to your primary care therapist or family doctor before taking Kitos Cell LP. Remember that self-medication can increase your risks for other illnesses and harm your health.
|Organs and systems
|Side effects KitosCell
|The immune system
|Anorexia, weight loss.
|central nervous system
|Insomnia, headache, dizziness.
|Upper respiratory tract infections, shortness of breath, cough, productive cough.
|Diarrhea, nausea, dispersion.
|Vomiting, more in the abdomen, constipation, gastritis.
|Liver and biliary tract
|Increased activity of ALT, ACT, GGT.
|An increase in serum bilirubin concentration together with an increase in the concentration of ALT and ACT activity.
|Rash and itching.
|Photosensitivity and sunburn, dry skin, itchy rash.
You can order pills online in the United States without a prescription at a Mexican online pharmacy.
To decrease the load through the liver and lungs, it is recommended to follow a healthy diet and quit smoking as soon as possible. Consult your doctor about the physical activities possible during the Kitoscell treatment course. Note that nicotine decreases the efficiency of the active agents contained in the medication.
Speaking about the treatment of skin issues like scars and scratches, the patient should avoid intensive massages and deep pilling with cosmetical products. If one or several pills were missed by the patient, it is not recommended to take the doubled dose next time. Put the missed tablet away and continue your regular intake of the anti-fibrosis medication.
Inform your doctor if you have missed more than 5 pills during the treatment course. The healthcare specialists will recommend passing a blood test and other examinations to change the dosage plan properly and timely. This way the efficiency of the therapy will not be lost.
Other names for the drug Pirfenidone: Pirfenidona (Mexico), Kitoscell. All drug names will be mentioned in these instructions. Pirfenidone is an immunosuppressant used to treat mild to moderate primary pulmonary fibrosis in adults.
Studies have shown that Pirfenidone is also effective in treating fibrotic conditions in other organs, including the kidneys and liver.
Idiopathic pulmonary fibrosis (IPF) is a condition in which lung tissue swells and forms scars over time, making it difficult to breathe deeply. Thus, the lungs have difficulty functioning properly.
Pirfenidone helps shrink the scar tissue and swelling in your lungs, thereby allowing you to breathe better.
Pirfenidone: mechanism of action
It is known from in vitro and animal studies that it has anti-inflammatory, antioxidant, and antifibrotic properties.
Pirfenidone reduces the proliferation of fibroblasts and other substances involved in the formation of fibrous tissue, thereby slowing the progression of idiopathic pulmonary fibrosis. This compound has been shown to inhibit the action of TGF-β1, a key cytokine involved in fibrogenesis.
What is Pirfenidone used for? Pirfenidona: para que sirve?
For the treatment of adults with mild to moderate idiopathic pulmonary fibrosis (IPF). The disease causes the lungs to become stiff, and it takes more force for gas exchange to occur. This is further hindered by scarring of the tissue. As a result, there is less oxygen in the blood (hypoxemia).
Persistent fatigue, low physical endurance, and cough are characteristics of pulmonary fibrosis. Respiratory rate first increases during exertion and then at rest (dyspnea), and physical performance gradually decreases.
For the treatment of liver fibrosis. A disease in which changes occur in the liver when it undergoes significant, chronic, or repetitive damage. These changes manifest as fibrous scar tissue, which replaces the damaged functional cells of the liver.
The drug modulates and reduces the formation of fibrous tissue. It prevents, controls, and causes regression of fibrosis.
Pirfenidone: side effects
The most common adverse reactions while taking Pirfenidona (Pirfenidone) were:
- skin rash;
- photosensitivity reaction;
- urinary tract infections;
Hypersensitivity to the sun: Pirfenidone use may make your skin more sensitive to the sun. When taking this medication, avoid exposure to direct and indirect sunlight, including sunlamps and sunlight falling through windows. Furthermore, use an effective sunscreen daily (at least SPF 50 for UVA and UVB), and wear clothing that protects you from the sun’s rays (such as a hat, and sweatshirt).
If you experience skin reactions (e.g., rashes, sunburns, blisters, peeling) caused by sun exposure, see your doctor.
This medicine can affect your liver function. Your doctor will monitor your liver function by doing regular blood tests while you are taking this medicine. If you experience symptoms that indicate liver problems such as nausea, vomiting, diarrhea, loss of appetite or weight loss, yellowing of the skin or whites of the eyes, the appearance of dark urine or pale stools, itching during treatment with Pirfenidone, do not delay a consultation with your doctor. If you have serious liver issues, you should not take this medicine.
Adverse reactions in patients have been mostly mild to moderate, which can be resolved by lowering the dose or stopping treatment.
Dosage and route of administration
The route of administration of Kitoscell 600 mg is oral. You should take the medication with food to reduce the risk of gastrointestinal side effects. At the beginning of treatment, the dose should be gradually increased over 14 days to the recommended maximum daily dose.
Several factors need to be considered to determine the dose a person needs: weight, medical condition, and taking other medications. If your doctor has recommended a dose that differs from the instructions, do not change the way you take medicine without first consulting your doctor. Usual doses (daily) for adults: 800-2400 mg.
Contraindications for the use of Pirfenidone
Do not use this medicine in the following cases:
- Allergy to Pirfenidone or any ingredient of the medicine;
- History of angioedema after using Pirfenidone;
- Presence of significant kidney or dialysis problems;
- The presence of serious liver problems;
- Taking a medicine called Fluvoxamine.
If you have kidney disease, talk to your doctor about how Pirfenidone may affect your condition. Furthermore, you should discuss, how the disease impacts the dosage and effectiveness of this medicine, as well as the need for special medical examinations. You should not take this medication if your kidney function has been severely reduced or if you are being treated with dialysis.
Before using any medication, be sure to tell your doctor about any illnesses or allergies you may have, any medications you are taking, and any other important facts about your health. Women should indicate if they are pregnant or breastfeeding. These factors may influence how to use Pirfenidone correctly. Your doctor may recommend that you stop taking it.
Can I take it during pregnancy and breastfeeding?
The medicine should not be used during pregnancy. If pregnancy occurs during treatment with Pirfenidone, consult your doctor immediately.
Breastfeeding: It is not fully known whether Pirfenidone passes into breast milk. If you take the drug while breastfeeding, you should be aware that it may impact the baby’s health.
Consult your doctor to find out whether you should continue breastfeeding or stop taking the drug.
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